微生物学博士，讲师、硕士生导师。欧博官网食品与生物工程学院教师。

E-mail：tangjianli@csust.edu.cn

【个人简介】

2014年欧博官网获工学学士学位，2021年湖南师范大学获理学博士学位。2022年4月至今，欧博官网食品与生物工程学院讲师、硕士生导师，“功能微生物创制及精准发酵研究团队”核心成员之一。研究方向为食品微生物代谢工程与合成生物学，主要从事食品功能微生物的挖掘、机制解析、代谢调控、定向改造等食品微生物技术研究。在Journal of Agricultural and Food Chemistry、Microbial Cell Factories、ACS synthetic biology等SCI期刊发表论文16篇。主持湖南省自然科学基金青年项目1项，湖南省教育厅优秀青年项目1项，长沙市自然科学基金青年项目1项，参与完成科技部“973计划”专项项目及国家自然科学基金面上项目各1项。

【主讲课程】

本科生：《微生物学》、《微生物学实验》、《生物工程综合实验》

硕士生：《高级微生物学》、《现代食品微生物学》、《基因工程》

博士生：《酶工程研究进展》

【主要研究领域】

1.传统发酵食品功能微生物资源挖掘

2.微生物代谢工程及其调控

3.微生物基因编辑及合成生物学

【主要科研项目】

1.湖南省自然科学青年基金项目：食窦魏斯氏菌降解酿造酱油中有害生物胺的机制研究（2024JJ6022），5万元，2024-2026年，主持

2.湖南省教育厅优秀青年基金项目：降生物胺魏斯氏菌的筛选及其关键基因的解析（23B0306），6万元，2023-2025年，主持

【主要科研论文】

1.Jianli Tang, Haocheng He, Yunlong Li, Zhudong Liu, Ziyuan Xia, Li Cao, Zirong Zhu, Ling Shuai, Yang Liu, Qianqian Wan, Yuewen Luo, Youming Zhang, Jie Rang* and Liqiu Xia*. Comparative proteomics reveals the effect of transcriptional regulator Sp13016 on butenyl-spinosyn biosynthesis in Saccharopolyspora pogona [J]. Journal of Agricultural and Food Chemistry, 2021, 69(42): 12554-12565.

2.Jianli Tang, Jianming Chen, Yang Liu, Jinjuan Hu, Ziyuan Xia, Xiaomin Li, Haocheng He, Jie Rang, Yunjun Sun, Ziquan Yu, Jun Cui and Liqiu Xia*. The global regulator PhoU positively controls growth and butenyl-spinosyn biosynthesis in Saccharopolyspora pogona [J]. Frontiers in Microbiology, 2022, 13: 904627.

3.Jianli Tang, Zirong Zhu, Haocheng He, Zhudong Liu, Ziyuan Xia, Jianming Chen, Jinjuan Hu, Li Cao, Jie Rang*, Ling Shuai, Yang Liu, Yunjun Sun, Xuezhi Ding, Shengbiao Hu, Liqiu Xia*. Bacterioferritin: a key iron storage modulator that affects strain growth and butenyl-spinosyn biosynthesis in Saccharopolyspora pogona [J]. Microbial Cell Factories, 2021, 20(1): 157.

4.Haocheng He, Jianli Tang, Jianming Chen, Jinjuan Hu, Zirong Zhu, Yang Liu, Ling Shuai, Li Cao, Zhudong Liu, Ziyuan Xia, Xuezhi Ding, Shengbiao Hu, Youming Zhang, Jie Rang*, Liqiu Xia*. Flaviolin-like gene cluster deletion optimized the butenyl-spinosyn biosynthesis route in Saccharopolyspora pogona [J]. ACS synthetic biology, 2021, 10(10):2740-2752.

5.Fan Huang, Jianli Tang, Lian He, Xuezhi Ding, Shaoya Huang, Youming Zhang, Yunjun Sun and Liqiu Xia*. Heterologous expression and antitumor activity analysis of syringolin from Pseudomonas syringae pv. syringae B728a [J]. Microbial Cell Factories, 2018, 17(1): 31.

6.Zhudong Liu, Zirong Zhu, Jianli Tang, Haocheng He, Qianqian Wan, Yuewen Luo, Weitao Huang, Ziquan Yu, Yibo Hu, Xuezhi Ding and Liqiu Xia*. RNA-seq-based transcriptomic analysis of Saccharopolyspora spinosa revealed the critical function of PEP phosphonomutase in replenishment pathway [J]. Journal of Agricultural and Food Chemistry, 2020, 68(49):14660-14669.

7.Zhudong Liu, Jie Xiao, Jianli Tang, Yang Liu, Ling Shuai, Li Cao, Ziyuan Xia, Xuezhi Ding, Jie Rang*, Liqiu Xia*. Effects of acuC on the growth development and spinosad biosynthesis of Saccharopolyspora spinosa [J]. Microbial Cell Factories, 2021, 20(1): 141.

8.Lian He, Huijun Yang, Jianli Tang, Zhudong Liu, Yiyan Chen, Binghua Lu, Haocheng He, Sijia Tang, Yunjun Sun, Fei Liu, Xuezhi Ding, Youming Zhang, Shengbiao Hu* and Liqiu Xia*. Intestinal probiotics E. coli Nissle 1917 as a targeted vehicle for delivery of p53 and Tum-5 to solid tumors for cancer therapy [J]. Journal of Biological Engineering, 2019, 13: 58.