1、个人基本信息：

姓    名：项炬

性    别：男

出生年月：1983年2月

技术职称：副教授

毕业院校：中南大学

学历（学位）：博士

所在学科：计算机科学与技术

研究方向：生物信息学、机器学习、人工智能、复杂系统

2、教育背景：

2001.09~2005.06

湘潭大学

学士

2005.09~2008.06

湘潭大学

硕士

2018.09~2022.06

中南大学

博士

3、目前研究领域：

生物信息学、机器学习、人工智能、复杂系统

4、已完成或已在承担的主要课题：

主持国家自然科学基金项目、湖南省自然科学基金项目、长沙市科技局项目、湖南省教育厅科学研究项目等共计7项，参与各类课题5项，主要课题情况如下。

[1]长沙市科技局平台和人才计划（重点），kq1802024，长沙市杰出创新青年培养计划－项炬，2018/11~2023/11，在研，主持.

[2]国家自然科学基金，61702054，基于网络重构和多尺度模块分解的人类疾病基因预测方法研究，2018/01~2020/12，已结题，主持. 

[3]湖南省自然科学基金，2018JJ3568，基于随机块模型（SBM）的疾病基因预测方法研究，2018/01~2020/12，已结题，主持.

[4]湖南省教育厅项目，14C0126，复杂网络的模块结构探测及其应用研究，2014/09-2016/09，已结题，主持.  

[5]科技部重点研发计划，2019YFA0706202，面向抑郁障碍早期识别的多模态心理、生理信息获取技术及有效特征研究，2020/01~2024/12，在研，参与. 

[6]湖南省自然科学基金，2018JJ2461，利用大数据挖掘研究衰老、老年性疾病和抗衰老药物，2018/01~2020/12，已结题，参与. 

6、已发表的学术论文：

[1]Jinlong Ma, Tian Qin, Ju Xiang*（通讯）. Disease-gene prediction based on preserving structure network embedding, Frontiers in Aging Neuroscience, 2023, 15: 1061892.

[2]Yan Zhang#, Ju Xiang#*（共一、通讯）, Liang Tang, Jialiang Yang*, Jianming Li*. PGAGP: Predicting pathogenic genes based on adaptive network embedding algorithm, Frontiers in Genetics, 2023, 13: 1087784.

[3]Yibai Wang#, Ju Xiang#*（共一、通讯）, Cuicui Liu, Min Tang, Rui Hou, Meihua Bao, Geng Tian, Jianjun He*, Binsheng He*, Drug repositioning for SARS-CoV-2 by Gaussian kernel similarity bilinear matrix factorization, Frontiers in Microbiology, 2022, 13: 1062281.

[4]Ju Xiang, Xiangmao Meng, Yichao Zhao, Fang-Xiang Wu, Min Li*. HyMM: hybrid method for disease-gene prediction by integrating multiscale module structure, Briefings in Bioinformatics, 2022, 23: bbac072.  

[5]Ju Xiang, Jiashuai Zhang, Yichao Zhao, Fang-Xiang Wu, Min Li*. Biomedical data, computational methods and tools for evaluating disease-disease associations, Briefings in Bioinformatics, 2022, 23(2): bbac006.  

[6]Ju Xiang, Jiashuai Zhang, Ruiqing Zheng, Xingyi Li, Min Li*. NIDM: network impulsive dynamics on multiplex biological network for disease-gene prediction, Briefings in Bioinformatics, 2021, 22: bbab080.  

[7]Ju Xiang#, Ning-Rui Zhang#, Jia-Shuai Zhang, Xiao-Yi Lv, Min Li*. PrGeFNE: Predicting disease-related genes by fast network embedding, Methods, 2021, 192: 3-12.  

[8]Yan Zhang#, Ju Xiang#（共一）, Liang Tang, Jianming Li*, Qingqing Lu, Geng Tian, Bin-Sheng He*, Jialiang Yang*. Identifying breast cancer-related genes based on a novel computational framework involving KEGG pathways and PPI network modularity, Frontiers in Genetics, 2021, 12: 876.  

[9]Ke Hu, Ju Xiang*（通讯）, Yun-Xia Yu*, Liang Tang, Qin Xiang, Jian-Ming Li, Yong-Hong Tang, Yong-Jun Chen, Yan Zhang. Significance-based multi-scale method for network community detection and its application in disease-gene prediction, Plos One, 2020, 15: e0227244.  

[10]Ke Hu, Jing-Bo Hu, Liang Tang, Ju Xiang*（通讯）, Jin-Long Ma, Yuan-Yuan Gao, Hui-Jia Li*, Yan Zhang*. Predicting disease-related genes by path structure and community structure in protein–protein networks, J. Stat. Mech., 2018, 2018: 100001.  

[11]Ju Xiang, Yan Zhang, Jian-Ming Li, Hui-Jia Li, Min Li*. Identifying multi-scale communities in networks by asymptotic surprise, J. Stat. Mech., 2019, 2019: 033403.

[12]Ju Xiang, Yan-Ni Tang, Yuan-Yuan Gao, Lang Liu, Yi Hao*, Jian-Ming Li*, Yan Zhang*, Shi Chen. Phase transition of Surprise optimization in community detection, Physica A, 2018, 491: 693-707.

[13]Ju Xiang, Hui-Jia Li*, Zhan Bu, Zhen Wang, Mei-Hua Bao, Liang Tang, Jian-Ming Li*. Critical analysis of (Quasi-)Surprise for community detection in complex networks, Sci. Rep., 2018, 8: 14459.

[14]Shi Chen, Zhi-Zhong Wang, Liang Tang, Yan-Ni Tang, Yuan-Yuan Gao, Hui-Jia Li, Ju Xiang*（通讯）, Yan Zhang*. Global vs local modularity for network community detection, Plos One, 2018, 13: e0205284.  

[15]Shi Chen, Zhi-Zhong Wang, Mei-Hua Bao, Liang Tang, Ji Zhou, Ju Xiang*（通讯）, Jian-Ming Li*, Chen-He Yi. Adaptive multi-resolution Modularity for detecting communities in networks, Physica A, 2018, 491: 591-603.

[16]Ju Xiang, Zhi-Zhong Wang, Hui-Jia Li*, Yan Zhang, Fang Li, Li-Ping Dong, Jian-Ming Li*, Li-Juan Guo*. Community detection based on significance optimization in complex networks, J. Stat. Mech., 2017, 2017: 053213.

[17]Ju Xiang, Zhi-Zhong Wang, Hui-Jia Li*, Yan Zhang, Shi Chen, Cui-Cui Liu, Jian-Ming Li*, Li-Juan Guo*. Comparing local modularity optimization for detecting communities in networks, International Journal of Modern Physics C, 2017, 28: 1750084.

[18]Hui-Jia Li, Ju Xiang*（通讯）. Explore of the fuzzy community structure integrating the directed line graph and likelihood optimization, Journal of Intelligent & Fuzzy Systems, 2017, 32: 4503-4511.

[19]Ju Xiang, Tao Hu, Yan Zhang*, Ke Hu, Yan-Ni Tang, Yuan-Yuan Gao, Ke Deng. Linear analysis of degree correlations in complex networks, Pramana, 2016, 87: 84.

[20]Ju Xiang, Tao Hu, Yan Zhang*, Ke Hu*, Jian-Ming Li, Xiao-Ke Xu, Cui-Cui Liu, Shi Chen. Local modularity for community detection in complex networks, Physica A, 2016, 443: 451-459.

[21]Ju Xiang, Ke Hu*, Yan Zhang, Mei-Hua Bao, Liang Tang, Yan-Ni Tang, Yuan-Yuan Gao, Jian-Ming Li*, Benyan Chen, Jing-Bo Hu. Enhancing community detection by using local structural information, J. Stat. Mech., 2016, 2016: 033405.

[22]Ju Xiang, Yan-Ni Tang, Yuan-Yuan Gao, Yan Zhang*, Ke Deng, Xiao-Ke Xu, Ke Hu*. Multi-resolution community detection based on generalized self-loop rescaling strategy, Physica A, 2015, 432: 127-139.

[23]Ju Xiang*, Tao Hu, Ke Hu*, Yan-Ni Tang, Yuan-Yuan Gao, Chun-Hong Chai, Xi-Jun Liu. Analysis of community-detection methods based on Potts spin model in complex networks, Canadian Journal of Physics, 2015, 93: 418-423.

[24]Ju Xiang, Ke Hu*, Yan Zhang*, Tao Hu, Jian-Ming Li. Analysis and perturbation of degree correlation in complex networks, Europhys. Lett., 2015, 111: 48003.

[25]Hai-Long Yan, Ju Xiang*（通讯）, Xiao-Yu Zhang, Jun-Feng Fan, Fang Chen, Gen-Yi Fu, Er-Min Guo, Xin-Guang Hu, Ke Hu, Ru-Min Wang. Community detection using global and local structural information, Pramana, 2013, 80: 173-185.

[26]Xin-Guang Hu, Ju Xiang*（通讯）, Zheng Jiao, Yang Liu, Guo-Qiu Xie, Ke Hu. Boson bound states in the β-Fermi–Pasta–Ulam model, Pramana, 2013, 81: 839-848.

[27]Ju Xiang, Xin-Guang Hu, Xiao-Yu Zhang, Jun-Feng Fan, Xian-Lin Zeng, Gen-Yi Fu, Ke Deng, Ke Hu*. Multi-resolution modularity methods and their limitations in community detection, Eur. Phys. J. B, 2012, 85: 1-10.

[28]Ju Xiang*, Ke Hu. Limitation of multi-resolution methods in community detection, Physica A, 2012, 391: 4995-5003.

[29]Ju Xiang, Ke Hu, Yi Tang*. A class of improved algorithms for detecting communities in complex networks, Physica A, 2008, 387: 3327-3334.

[30]Ruixin He, Fengjiao He, Zhenliang Hu, Yifang He, Xinting Zeng, Yao Liu, Liang Tang, Ju Xiang, Jianming Li, Binsheng He, Qin Xiang. Analysis of Potential Mechanism of Herbal Formula Taohong Siwu Decoction against Vascular Dementia Based on Network Pharmacology and Molecular Docking, BioMed Research International, 2023, 2023: 1235552.

[31]Binsheng He, Kun Wang, Ju Xiang, Pingping Bing, Min Tang, Geng Tian, Cheng Guo, Miao Xu, Jialiang Yang. DGHNE: network enhancement-based method in identifying disease-causing genes through a heterogeneous biomedical network, Briefings in Bioinformatics, 2022, 23(6): bbac405.

[32]Xiangmao Meng, Wenkai Li, Ju Xiang, Hayat-Dino Bedru, Wenkang Wang, Fang-Xiang Wu, Min Li*. Temporal-Spatial Analysis of the Essentiality of Hub Proteins in Protein-Protein Interaction Networks, IEEE Transactions on Network Science and Engineering, 2022, 9(5): 3504-3514.

[33]Xingyi Li, Min Li*, Ju Xiang, Zhelin Zhao, Xuequn Shang*. SEPA: Signalling entropy-based algorithm to evaluate personalized pathway activation for survival analysis on pan-cancer data, Bioinformatics, 2022, btac122, https://doi.org/10.1093/bioinformatics/btac122.

[34]Yuhua Yao, Binbin Ji, Yaping Lv, Ling Li, Ju Xiang, Liao Bo, Wei Gao*. Predicting lncRNA-disease association by a random walk with restart on multiplex and heterogeneous networks, Frontiers in Genetics, 2021, 12: 1483.

[35]Shaoqing Lv, Ju Xiang, Yiyang Li, Xincheng Ren, Guangyue Lu. MERP: Motifs enhanced network embedding based on edge reweighting preprocessing, Frontiers in Physics, 2022, 10.

[36]Qin Xiang, Yanna Cao, Hongbo Xu, Zhijian Yang, Liang Tang, Ju Xiang, Jianming Li, Hao Deng, Lamei Yuan*. Novel MFSD8 Variants in a Chinese Family with Nonsyndromic Macular Dystrophy, Journal of Ophthalmology, 2021, 2021: 6684045.

[37]Wenkang Wang, Xiangmao Meng, Ju Xiang, Min Li*, Overlapping Protein Complexes Detection Based on Multi-level Topological Similarities, in, Springer International Publishing, Cham, 2021, pp. 215-226.

[38]Liang Tang, Qin Xiang, Ju Xiang, Jianming Li*. lncRNA-Associated Competitive Endogenous RNA Regulatory Network in an Aβ(25-35)-Induced AD Mouse Model Treated with Tripterygium Glycoside, Neuropsychiatr Dis Treat, 2021, 17: 1531-1541.

[39]Xiangmao Meng, Ju Xiang, Ruiqing Zheng, Fang-Xiang Wu, Min Li*. DPCMNE: detecting protein complexes from protein-protein interaction networks via multi-level network embedding, IEEE/ACM Transactions on Computational Biology and Bioinformatics, 2021, DOI:10.1109/TCBB.2021.3050102.

[40]Xingyi Li, Ju Xiang, Fang-Xiang Wu, Min Li*. NetAUC: A network-based multi-biomarker identification method by AUC optimization, Methods, 2021, https://doi.org/10.1016/j.ymeth.2021.1008.1001.

[41]Xingyi Li, Ju Xiang, Fang-Xiang Wu, Min Li*. A dual ranking algorithm based on the multiplex network for heterogeneous complex disease analysis, IEEE/ACM Transactions on Computational Biology and Bioinformatics, 2021, DOI: 10.1109/TCBB.2021.3059046.

[42]Lijuan Zhu, Ju Zhang, Yi Zhang, Jidong Lang, Ju Xiang, Xiaogang Bai, Na Yan, Geng Tian, Huajun Zhang*, Jialiang Yang*. NAIGO: An Improved Method to Align PPI Networks Based on Gene Ontology and Graphlets, Frontiers in Bioengineering and Biotechnology, 2020, 8: 547.

[43]Lijuan Zhu, Ju Xiang, Qiuling Wang, Ailan Wang, Chao Li, Geng Tian, Huajun Zhang*, Size Chen*. Revealing the Interactions Between Diabetes, Diabetes-Related Diseases, and Cancers Based on the Network Connectivity of Their Related Genes, Frontiers in Genetics, 2020, 11.

[44]Renyi Zhou, Zhangli Lu, Huimin Luo, Ju Xiang, Min Zeng, Min Li*. NEDD: a network embedding based method for predicting drug-disease associations, BMC Bioinformatics, 2020, 21: 387.

[45]Liang Tang#, Yongjun Chen#, Qin Xiang, Ju Xiang, Yonghong Tang*, Jianming Li*. The association between IL18 , FOXP3 and IL13 genes polymorphisms and risk of allergic rhinitis: a meta-analysis, Inflammation Research, 2020, 69: 911-923.

[46]Liang Tang#, Yongjun Chen#, Qin Xiang, Ju Xiang, Yonghong Tang*, Jianming Li#*. The GCAG Haplotype of the CRHBP Gene May Decrease the Risk for Robbery Behavior Among the Han Chinese, Genetic Testing and Molecular Biomarkers, 2020, 24: 436-442.

[47]Chuanying Liu, Dong Wei, Ju Xiang, Fuquan Ren, Li Huang, Jidong Lang, Geng Tian, Yushuang Li*, Jialiang Yang*. An Improved Anticancer Drug-Response Prediction Based on an Ensemble Method Integrating Matrix Completion and Ridge Regression, Molecular Therapy - Nucleic Acids, 2020, 21: 676-686.

[48]Xingyi Li, Ju Xiang, Fang-Xiang Wu, Min Li*. A topological AUC-based biomarker ensemble method for the complex disease analysis, in:  2020 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), 2020, pp. 281-286.

[49]Xingyi Li, Ju Xiang, Jianxin Wang, Jinyan Li, Fang-Xiang Wu, Min Li*. FUNMarker: Fusion network-based method to identify prognostic and heterogeneous breast cancer biomarkers, IEEE/ACM Transactions on Computational Biology and Bioinformatics, 2020, DOI: 10.1109/tcbb.2020.2973148.

[50]Xingyi Li, Min Li*, Ruiqing Zheng, Xiang Chen, Ju Xiang, Fang-Xiang Wu, Jianxin Wang. Evaluation of Pathway Activation for a Single Sample Toward Inflammatory Bowel Disease Classification, Frontiers in Genetics, 2020, 10.

[51]Jianming Li, Yongjun Chen, Qin Xiang, Ju Xiang, Yonghong Tang*, Liang Tang*. 5HTTLPR polymorphism and postpartum depression risk: A meta-analysis, Medicine, 2020, 99.

[52]Shaoqing Lv, Ju Xiang, Jingyu Feng, Honggang Wang, Guangyue Lu, Min Li*. Community enhancement network embedding based on edge reweighting preprocessing, J. Stat. Mech., 2020, 2020: 103403.

[53]Liqian Zhou#, Zejun Li#, Jialiang Yang, Geng Tian, Fuxing Liu, Hong Wen, Li Peng, Min Chen, Ju Xiang, Lihong Peng*. Revealing Drug-Target Interactions with Computational Models and Algorithms, Molecules, 2019, 24: 1714.

[54]Xingyi Li, Ju Xiang, Jianxin Wang, Fang-Xiang Wu, Min Li*. Identification of Prognostic and Heterogeneous Breast Cancer Biomarkers Based on Fusion Network and Multiple Scoring Strategies, in, Springer International Publishing, Cham, 2019, pp. 529-534.

[55]Xingyi Li, Ju Xiang, Xinyu Hu, Fang-Xiang Wu, Min Li*. DualRank: multiplex network-based dual ranking for heterogeneous complex disease analysis, in:  2019 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), 2019, pp. 812-817.

[56]郝一, 张煦, 李红超, 项炬*. 糖类抗原19-9及噬酸粒细胞与血红蛋白鉴别自身免疫性胰腺炎与胰腺癌的临床价值研究, 中国全科医学, 2018, 21: 1-5.

[57]Liang Tang, Jianming Li, Meihua Bao, Ju Xiang, Yiwei Chen*, Yan Wang*. Genetic association between HER2 and ESR2 polymorphisms and ovarian cancer: a meta-analysis, OncoTargets and Therapy, 2018, pp. 1055-1066.

[58]Yan Wang, Lianghui Chen, Fang Li, Meihua Bao, Jie Zeng, Ju Xiang, Huaiqing Luo, Jianming Li*, Liang Tang*. TLR4 rs41426344 increases susceptibility of rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA) in a central south Chinese Han population, Pediatric Rheumatology, 2017, 15: 12.

[59]Liang Tang*, Shui Zheng, Yan Wang, Fang Li, Meihua Bao, Jie Zeng, Ju Xiang, Huaiqing Luo, Jianming Li. Rs4265085 in GPER1 gene increases the risk for unexplained recurrent spontaneous abortion in Dai and Bai ethnic groups in China, Reproductive BioMedicine Online, 2017, 34: 399-405.

[60]Liang Tang, Yan Wang, Yiwei Chen, Lianghui Chen, Shui Zheng, Meihua Bao, Ju Xiang, Huaiqing Luo, Jianming Li*, Yungui Li*. The Association between 5HT2A T102C and Behavioral and Psychological Symptoms of Dementia in Alzheimer's Disease: A Meta-Analysis, BioMed Research International, 2017, 2017: 14.

[61]Jianming Li, Liang Tang, Yan Wang, Fang Li, Meihua Bao, Ju Xiang, Deliang Lei*, Beisha Tang*. Genetic Associations and Interactions Between the NR3C1 (GR) and NR3C2 (MR) Genes and Aggressive Behavior in a Central South Chinese Han Population, Genetic Testing and Molecular Biomarkers, 2017, 21: 497-505.

[62]Guang-yi Li, Zi-bo Li, Fang Li, Li-ping Dong, Liang Tang, Ju Xiang, Jian-ming Li*, Mei-hua Bao*. Meta-Analysis on the Association of ALDH2 Polymorphisms and Type 2 Diabetic Mellitus, Diabetic Retinopathy, Int J Environ Res Public Health, 2017, 14: 165.

[63]鲁昀芳, 李宝, 李建明, 项炬, 李芳, 鲍美华, 唐亮*. 小鼠HHEX基因和蛋白的生物信息学分析, 生物技术通讯(Letters in Biotechnology), 2016 27.

[64]Jian-Ming Li, Yan Zhang, Liang Tang, Yong-Heng Chen, Qian Gao, Mei-Hua Bao, Ju Xiang, De-Liang Lei*. Effects of triptolide on hippocampal microglial cells and astrocytes in the APP/PS1 double transgenic mouse model of Alzheimer’s disease, Neural Regeneration Research（中国神经再生研究（英文版））, 2016, 11: 1492-1498.

[65]Mei-Hua Bao*, Huai-Qing Luo, Ju Xiang, Liang Tang, Li-Ping Dong, Guang-Yi Li, Jie Zeng, Jian-Ming Li*. Meta-Analysis for the Association between Polymorphisms in Interleukin-17A and Risk of Coronary Artery Disease, Int J Environ Res Public Health, 2016, 13: 660.

[66]Mei-hua Bao*, Huai-qing Luo, Li-hua Chen, Liang Tang, Kui-fen Ma, Ju Xiang, Li-ping Dong, Jie Zeng, Guang-yi Li, Jian-ming Li*. Impact of high fat diet on long non-coding RNAs and messenger RNAs expression in the aortas of ApoE(−/−) mice, Sci. Rep., 2016, 6: 34161.

[67]Yan Xiao, Mei-Hua Bao*, Huai-Qing Luo, Ju Xiang, Jian-Ming Li*. A Meta-Analysis of the Association between Polymorphisms in MicroRNAs and Risk of Ischemic Stroke, Genes, 2015, 6: 1283-1299.

[68]Ke Hu, Ju Xiang, Xiao-Ke Xu*, Hui-Jia Li, Wan-Chun Yang, Yi Tang. Predicting the growth of new links by new preferential attachment similarity indices, Pramana, 2014, 82: 571-583.

[69]Benyan Chen, Ju Xiang, Ke Hu, Yi Tang. Enhancing betweenness algorithm for detecting communities in complex networks, Modern Physics Letters B, 2014, 28: 1450074.

7、所获学术荣誉及学术影响：

[1]会员：

中国计算机学会会员

中国人工智能学会会员

中国生物工程学会计算与生信专委会委员

湖南省神经科学学会理事

[2]期刊审稿人：

Swarm and Evolutionary Computation, IEEE Systems Journal，IEEE-ACM Transactions on Computational Biology and Bioinformatics，Knowledge and Information Systems，APBC2023 PC member，Frontiers in Aging Neuroscience，Frontiers in Genetics，Frontiers in Oncology，Frontiers in Physics，Frontiers in Applied Mathematics and Statistics, Scientific Reports，International Journal of Systems Science，Physica A, 中国物理, Chinese Physics B, Canadian Journal of Physics, International Journal of Modern Physics B, Peer-to-Peer Networking and Applications, 等.  

[3]项目评审专家：

国家自然科学基金，浙江省自然科学基金，广东省自然科学基金，江西省自然科学基金，广西壮族自治区科学技术厅专家库成员.